J Korean Assoc Oral Maxillofac Surg 2008; 34(5): 550~554
FEATURES OF HISTOPATHOLOGIC AND RADIOGRAPHIC FINDINGS
IN BISPHOSPHONATE-RELATED OSTEONECROSIS OF JAW-CLINICAL REVIEW
Joo-Young Ohe, Yong-Dae Kwon, Yeo-Gab Kim, Baek-Soo Lee,
Byoung-Wook Yoon, Byoung-Jun Choi
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Bisphosphonates (BPs) are a class of agent used to treat patient with osteoporosis or malignant bone metastases. BPs can be categorized into 2
groups: nitrogen-containing and non-nitrogen containing. Nitrogen-containing BPs are considered to have more toxicity. Despite their clinical benefits,
bisphosphonate-related osteonecrosis of jaw(BRONJ) is a significant complication to patients receveing these drugs.
Since the first description of BRONJ in 2003 by Marx, the number of reports on BRONJ has been rapidly increasing. BRONJ is considered as an
emerging problem in oral & maxillofacial surgery.
Generally, osteonecrosis in the maxilla is rare, however BRONJ is found both in the maxilla and the mandible. This is an important feature of
BRONJ compared to common infectious osteomyelitis of the jaw.
Growing number of case reports, suggest that bisphosphonate therapy may cause exposed, necrotic bone. BRONJ has simillar features compared to
IORN (infected osteoradionecrosis). BRONJ has meaningful features established through the interestigation on histopathologic and radiographic findings.
These features have an impact on treatment plan and prognosis. This presentation contemplates on features of histopathologic and radiographic
findings in bisphosphonate-related osteonecrosis of the jaw.
Keywords: Bisphosphonate, BRONJ, Alendronate

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