J Korean Assoc Oral Maxillofac Surg 2004; 30(2): 81~84
Blood viscosity change in oral squamous cell carcinoma xenotransplanted nude mice
Hoon Myoung, Jong-Ho Lee, Pill-Hoon Choung, Myung-Jin Kim
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
It is well known that malignant tumor have hypoxic cell fraction, which is radio resistant and is one of the most important cause of local recurrence after radiotherapy. One of the causes of hypoxia in tumor is blood flow decrease due to increase in blood flow resistance and one of the causes of increased blood flow resistance could be attributed to the increase in blood viscosity. For the evaluation of the change of blood viscosity in oral cancer, experiments were carried out to test the change of blood viscosity among the normal control and xenografted oral cancer nude mice. Relative viscosity measured against distilled water was 3.30±0.14 for normal control, and 3.67±0.62 for tumor bearing mice at the first time of blood sampling in experimental period (100 mm3 0.05). However, as the tumor grew, significant difference of blood viscosity was detected at the third time of blood sampling (control group:3.37±0.59, and experimental group: 4.31±0.41 300 mm3
Keywords: Oral cancer, Blood viscosity


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