Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 2.

Table. 2.

Characteristics of included studies

Study Study design Sample
characteristics
Intervention and form Application protocol. Control Measurement scale Outcome Adverse effects
Ricken et al.24 (2021) Interventional study 18 patients aged 30-69 years were recruited for application of capsaicin in a burning mouth region.
Duration: 90 days
0.025% capsaicin gel applied to the affected area.
Application protocol: thrice daily for one month, twice daily every alternate day for the second month, once daily for three days per week
Application protocol: thrice daily in gel form for one month, twice daily every alternate day for the second month, once daily for three days a week No control Subjective pain scores and quality of life using the OHIP-14 scale Topical application of capsaicin is effective in reducing the intensity of burning sensation. 7 patients (38%) reported xerostomia. 2 patients reported erythema on the lip and jugal mucosa.
Jørgensen and Pedersen23 (2017) Interventional study, randomized double-blind crossover study 22 female patients aged 34-70 years were recruited, of which 18 completed the study, crossover design application of capsaicin in the burning region. 0.025% and 0.01% capsaicin gels were applied on the dorsal part of the tongue. Capsaicin gel was applied three times a day for 14 days followed by a 14-day washout period. For the next 14 days, the other concentration was applied. No control Subjective pain scores using VAS There was a significant decrease in both the capsaicin groups (0.01% and 0.025%) and the VAS score in comparison to baseline.
The VAS score at baseline was 5.5±0.6, and there was a decrease of VAS by 1.4±0.4.
VAS scores increased in the wash out period.
There was no significant difference in either of the concentration groups.
4 patients reporting minor side effects were deferred from treatment.
Side effects were mostly related to gastrointestinal symptoms such as nausea, itching, and sore throat. All side effects were reversible.
Silvestre et al.25 (2012) Interventional study, randomized double-blind crossover study 30 patients were recruited for the study including 23 individuals aged 40-90 years.
Crossover design
0.02% capsaicin rinse for 7 days The total duration was three weeks.
Mouthwash administered thrice daily for one week, followed by a one-week washout period and then subjection to the control placebo mouthwash.
Placebo rinse Subjective pain scores using VAS There was a significant decrease in the VAS score in the capsaicin group. 7 dropouts
Side effects ranged from intense burning sensation in 30% of subjects ranging up to 30 minutes after application of the rinse.
Jankovskis and Selga22 (2021) Interventional study 89 patients, of which 20 were allocated to the capsaicin mouthwash group. 0.02% capsaicin rinse The total duration of therapy was three weeks. The patient was subjected to capsaicin mouth rinse three times a day for three weeks. Zinc and vitamin B12 supplementation Subjective pain scores using VAS Capsaicin mouth rinse in conjunction with B12 and zinc supplementation is effective in reducing VAS scores related to burning mouth syndrome. -

(OHIP-14: Oral Health Impact Profile-14, VAS: visual analog scale)

J Korean Assoc Oral Maxillofac Surg 2024;50:63~69
https://doi.org/10.5125/jkaoms.2024.50.2.63
© JKAOMS