Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 3.

Table. 3.

Cox regression for disease-free survival

Variable No. of patients No. of events Univariable Cox regression Multivariable Cox regression (backward selection)


HR (95% CI) P-value HR (95% CI) P-value
Sex
Female 89 34 1 (ref.)
Male 116 34 0.762 (0.474-1.227) 0.2638
Age
≤40 yr 33 13 1 (ref.)
>40 yr 172 55 0.867 (0.472-1.592) 0.6456
Addictions
Absent 83 21 1 (ref.)
Present 122 39 1.337 (0.796-2.246) 0.2718
T stage
T1 or T2 128 32 1 (ref.)
T3 or T4 77 36 2.072 (1.285-3.341) 0.0028
N stage
N0 124 23 1 (ref.) 1 (ref.)
N1 31 14 2.956 (1.519-5.753) 0.0014 2.499 (1.148-5.442) 0.0210
N2 or N3 50 31 4.553 (2.645-7.836) <0.0001 4.022 (2.124-7.614) <0.0001
TNM stage
Stage I or II (early) 100 18 1 (ref.)
Stage III or IV (advanced) 105 50 3.150 (1.834-5.412) <0.0001
Treatment
Surgery only 110 19 1 (ref.)
Surgery+RT/CT 77 39 3.357 (1.932-5.833) <0.0001
RT/CT 18 10 4.899 (2.271-10.566) <0.0001
Differentiation (missing 8 cases)
Well 97 25 1 (ref.)
Moderate 76 27 1.626 (0.942-2.808) 0.0812
Poor 24 13 2.486 (1.270-4.864) 0.0078
Depth of invasion (missing 32 cases)
≤5 mm 65 12 1 (ref.)
6-10 mm 37 11 1.625 (0.716-3.693) 0.2459
>10 mm 71 32 2.894 (1.488-5.628) 0.0017
Lymphovascular invasion (missing 18 cases)
Absent 144 40 1 (ref.)
Present 43 18 1.612 (0.924-2.814) 0.0926
Perineural invasion (missing 18 cases)
Absent 149 35 1 (ref.) 1 (ref.)
Present 38 23 3.375 (1.987-5.732) <0.0001 2.145 (1.192-3.860) 0.0109
Extranodal extension
Absent 165 41 1 (ref.)
Present 40 27 3.836 (2.345-6.274) <0.0001
Resection status (missing 18 cases)
Close (<5 mm) 63 27 1 (ref.)
Safe (≥5 mm) 124 31 0.547 (0.326-0.918) 0.0224

(HR: hazard ratio, CI: confidence interval, ref.: reference, RT: radiotherapy, CT: chemotherapy)

J Korean Assoc Oral Maxillofac Surg 2022;48:192~200
https://doi.org/10.5125/jkaoms.2022.48.4.192
© JKAOMS