Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 2.

Table. 2.

Cox regression for overall survival

Variable No. of patients No. of events Univariable Cox regression Multivariable Cox regression (backward selection)


HR (95% CI) P-value HR (95% CI) P-value
Sex
Female 89 22 1 (ref.)
Male 116 25 0.962 (0.543-1.707) 0.8959
Age
≤40 yr 33 11 1 (ref.)
>40 yr 172 36 0.685 (0.349-1.347) 0.2727
Addictions
Absent 83 16 1 (ref.)
Present 122 28 1.313 (0.720-2.394) 0.3739
T stage
T1 or T2 128 17 1 (ref.)
T3 or T4 77 30 3.302 (1.820-5.993) <0.0001
N stage
N0 124 10 1 (ref.) 1 (ref.)
N1 31 11 5.316 (2.256-12.528) 0.0001 4.684 (1.975-11.111) 0.0005
N2 or N3 50 26 8.616 (4.148-17.896) <0.0001 7.640 (3.588-16.266) <0.0001
TNM stage
Stage I or II (early) 100 6 1 (ref.)
Stage III or IV (advanced) 105 41 7.925 (3.361-18.686) <0.0001
Treatment
Surgery only 110 10 1 (ref.)
Surgery+RT/CT 77 32 5.433 (2.668-11.063) <0.0001
RT/CT 18 5 5.219 (1.778-15.319) 0.0026
Differentiation (missing 8 cases)
Well 97 14 1 (ref.) 1 (ref.)
Moderate 76 21 2.233 (1.133-4.399) 0.0203 1.932 (0.972-3.840) 0.0604
Poor 24 12 4.220 (1.946-9.149) 0.0003 2.181 (0.981-4.852) 0.0558
Depth of invasion (missing 32 cases)
≤5 mm 65 6 1 (ref.)
6-10 mm 37 7 2.005 (0.674-5.968) 0.2113
>10 mm 71 26 4.653 (1.913-11.315) 0.0007
Lymphovascular invasion (missing 18 cases)
Absent 144 27 1 (ref.)
Present 43 15 1.980 (1.053-3.724) 0.0339
Perineural invasion (missing 18 cases)
Absent 149 23 1 (ref.)
Present 38 19 3.951 (2.146-7.276) <0.0001
Extranodal extension
Absent 165 22 1 (ref.)
Present 40 25 5.701 (3.209-10.126) <0.0001
Resection status (missing 18 cases)
Close (<5 mm) 63 21 1 (ref.)
Safe (≥5 mm) 124 21 0.508 (0.278-0.931) 0.0283

(HR: hazard ratio, CI: confidence interval, ref.: reference, RT: radiotherapy, CT: chemotherapy)

J Korean Assoc Oral Maxillofac Surg 2022;48:192~200
https://doi.org/10.5125/jkaoms.2022.48.4.192
© JKAOMS