Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 7.

Table. 7.

Candidates for salivary biomarkers in oral cancer: based on biomolecules

Genomic markers Salivary transcriptome markers (mRNA) Salivary protein markers Other markers
-Mutation p53 genes codon 63-Promoter hypermethylation of:+DAPK gene+TIMP3 gene+p16 gene+MGMT gene-Cyclin D1 gene amplification-Decrease in mammary serine protease inhibitor (Maspin) -IL-8-IL-1-S100P-SAT (spermidine/spermine N1-acetyltransferase)-miR 125, miR 31, miR 200a -Elevated CD44-IL-6-Intermediate filament protein (Cyfra 21-1)-8-OHdG DNA damage marker (8-OHdG)-Albumin-Glutathione-Actin and myosin-L-phenylalanine-EFNB2, ANGPT1, ANGPT2, CD31, VEGF -Presence of HPV and EBV-Salivary non-organic compound: Na, Ca, F, Mg-Fucose
J Korean Assoc Oral Maxillofac Surg 2020;46:301~312
https://doi.org/10.5125/jkaoms.2020.46.5.301
© JKAOMS