Commercially available saliva collection devices and their key advantages20
| Device name | Company (city, country) | Dose/volume | Patent No. | Characteristics |
|---|---|---|---|---|
| OraSure | OraSure Tech. (Bethlehem, PA, USA) | The pad draws oral fluid, rich in antibodies | US8062908B2 | U.S. Food and Drug Administration (FDA) approved for HIV-1 testing. Easy and safe for public health screening, life insurance risk assessment, and good for outreach community programs. |
| Quantisal | Immunalysis Co. (Pomona, LA, USA) | 1 mL±10% | US8641642B2 | Contains cellulosic (paper-based) absorbent material for collection of saliva. |
| Salivette | Sarstedt AG & Co. KG (Nümbrecht, Germany) | 1.1±0.3 mL | US9113850B2 | Wide application range, including detection of HIV antibodies, oxidative stress steroid hormones for general wellness. |
| UltraSal-2 | Oasis Diagnostics Co. (Vancouver, WA, USA) | Up to 24 mL of the whole saliva | US9113850B2 | Large amount of saliva (24 mL). |
| Greiner Bio-One SCS | Greiner Bio-one (Monroe, NC, USA) | 4 mL of a tartrazine | US 20090017442 | Only device with internal dye (tartrazine) for 2 minutes used as a saliva quantification tool. Uses a colorimetric method. |
| RNAPro•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | 1.0 mL of saliva in 1-3 min | US, EU |
Simultaneous collection of RNA and proteins, including cell-free DNA, cell-free RNA, and exosomes. Large DNA and interfering factors removed. Useful for exploration of the salivary transcriptome and the salivary proteome. Built-in Sample Volume Adequacy Indicator (SVAI). |
| Pure•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | 4.0 mL | US, EU |
Collection of cell-free DNA, cell RNA total RNA, or proteins. Major impurities removed by a built-in filtration system. Built-in SVAI. |
| Super•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | 1.0 mL | US, EU |
Whole saliva collection system. Absorbent pad material removes interfering mucinous material. Shorter collection time due to the higher surface area of pad material exposed to fluid in the oral cavity. |
| Versi•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | A maximum sample volume of 1.4 mL | Patents pending | Whole saliva collection system. Absorbent pad material removes interfering mucinous material. |
| Pedia•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | A passive collection process with soother design to not only collect but also relax the infant. | Patents pending | Device for passive saliva collection from neonates and infants. Based on pacifier design. Collect whole saliva. |
| DNA•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | 3 mL | US D627882 | Saliva DNA Collection Kit – uses a buccal cell scrape followed by an oral rinse. |
| SimplOFy | Oasis Diagnostics Co., Vancouver, WA, USA | 2.0 mL of whole saliva | US20180235206; |
Saliva DNA Collection Kit for genomic DNA – consumer-oriented device, collects whole saliva by expectoration (spitting). |
| Micro•SAL | Oasis Diagnostics Co. (Vancouver, WA, USA) | 0.5 mL | US and EU Patents including US |
Device for collection of saliva from infants and neonates. Separate configuration available for collection from small animals. |
| OraGene Dx | DNA Genotek (Ottawa, ON, Canada) | 2 mL | 7,482,116; 8,221,381; D631,554 S; D640,795 S; 9,079,181; 9,523,115 | Saliva DNA collection kit for consumer-based genomic DNA collection. |
| OraGene Discover | DNA Genotek (Ottawa, ON, Canada) | 1 mL | OGR-500, OGR-500.005 kits: D640,795 S; 9,079,181; 9,523,115 | Saliva DNA collection device for research applications |
| OraGene RNA | DNA Genotek (Ottawa, ON, Canada) | 2 mL | 8,221,381; 9,207,164; 10,000,795 | Saliva RNA collection device |
| ORAcollect | DNA Genotek (Ottawa, ON, Canada) | 1 mL | 7,482,116; 8,728,414; D631,350 S and patent pending | Swab-based device for oral DNA collection. Pediatric version available as a separate product |
| ORACOL | Malvern Medical Developments (Worcester, UK) | 1 mL whole saliva | US8641642B2 | Foam/sponge device on a stick, mainly used for infectious disease antibody testing particularly measles, HIV, hepatitis A and B, mumps, syphilis, and rubella, but has also been used for substance abuse testing. |
| SalivaBio | SalivaBio LLC (State College, PA, USA) | 2 mL | EP2745112A1 | Range of products for collecting whole saliva from adults, children, and neonates. |
| i-Swab | Mawi DNA Tech. (Hayward, CA, USA) | 1 mL | US20140243706A1 | Collection of salivary DNA using swab-based materials |
| Saliva DNA Collection Device | Norgen Biotek Co. (Thorold, ON, Canada) | 2 mL | Patents pending | Expectoration (spitting) technique. |