Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 5.

Table. 5.

Metabolomics biomarkers identified in USWS for OSCC detection20

Candidate biomarkers Techniques Clinical significance References
Cadaverine, alanine, serine, glutamine, piperidine, taurine piperidine, choline, pyrroline hydroxycarboxylic acid, beta-alanine, alpha-aminobutyric acid betaine, tyrosine, leucine+isoleucine, histidine, tryptophan, glutamic acid, threonine, carnitine, pipercolic acid, lactic acid, phenylalanine and valine Capillary electrophoresis time-of-flight mass spectrometry (CE-TOF-MS) and HPLC with quadrupole/TOF MS Facilitates the clinical detection of OSCC and improves its diagnosis and prognosis. They have a high level of predictive value and serves as a stratification tool. Wei et al. 42 Sugimoto et al. 43
Hypoxanthine, guanine, guanosine, trimethylamine N-oxide, spermidine, pipecolate, methionine CE-TOF-MS Discrimination of controls from OSCC patients and all of these metabolites have elevated levels in saliva, and hence can be used in noninvasive oral cancer screening. Ishikawa et al. 44

(USWS: unstimulated whole saliva, OSCC: oral squamous cell carcinoma)

J Korean Assoc Oral Maxillofac Surg 2020;46:301~312