Journal of the Korean Association of Oral and Maxillofacial Surgeons : eISSN 2234-5930 / pISSN 2234-7550

Table. 4.

Table. 4.

Transcriptomic biomarkers identified in USWS for OSSC detection20

Candidate biomarkers Techniques Clinical significance References
Interleukin (IL)-1 , IL-8 ELISA Angiogenesis, cell adhesion, chemotaxis, immune response, replication, signal transduction, proliferation, inflammation, and apoptosis Li et al. 37 Elashoff et al. 38
Dual specificity phosphatase 1 (DUSP1) Quantitative PCR (qPCR) and microarrays followed by qPCR Oxidative stress, protein modification, signal transduction Li et al. 37
H3 histone family 3A (H3F3A) qPCR and microarrays followed by qPCR DNA binding activity Li et al. 37
Long noncoding HOTAIR qPCR and microarrays followed by qPCR Expression of HOTAIR is associated with p53 gene and causes DNA damage Tang et al. 39
miR-125a, miR-200a, miR-31 qPCR and microarrays followed by qPCR Posttranscriptional regulation by RNA silencing complex, cellular growth, and elevated levels in proliferation in OSCC Liu et al. 40 Park et al. 41

(USWS: unstimulated whole saliva, OSCC: oral squamous cell carcinoma, ELISA: enzyme-linked immunosorbent assay, PCR: polymerase chain reaction)

J Korean Assoc Oral Maxillofac Surg 2020;46:301~312