Description of oral disease proteomic analysis using unstimulated whole saliva (USWS)20
| Disease | Type of saliva | Proteomic approach | Proteins identified | References |
|---|---|---|---|---|
| Oral squamous cell carcinoma | USWS | Mass spectrometry (MS) and western blotting | Increased abundance of myosin and actin. | de Jong et al. 21 |
| USWS | Using shotgun proteomics approach (RP-HPLC, CP-LC with TOF and immunoassay) | Detection of 52 protein that presented in diseased samples but absent in healthy samples | Hu et al. 25 | |
| USWS | Using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) with hydrophilic interaction chromatography mode | ↑Level of choline, betaine and pipecolinic acid |
Wang et al.22 | |
| Oral leukoplakia | USWS | Two-dimensional gel electrophoresis, mass spectrometry, immunohistochemistry | 22 spots very abundant among them apolipoprotein A1, alpha-amylase, cystatins, keratin 10, lysozyme precursor, and CK10 were relevant to the study. | Camisasca et al. 23 |
| Proliferative verrucous leukoplakia | USWS | Mass spectrometry | Angiotensinogen (AGT) and dipeptidyl peptidase 1 (DPP1) | Flores et al. 24 |
| Premalignant lesions | USWS | Western blotting, mass spectrometry | Salivary actin and myosin | de Jong et al. 21 |