J Korean Assoc Oral Maxillofac Surg 2016; 42(5): 271~277
Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw
Seung Jae Paek1, Won-Jong Park3, Ho-Sung Shin2, Moon-Gi Choi3, Kyung-Hwan Kwon3, Eun Joo Choi3
1Department of Oral and Maxillofacial Surgery, Wonkwang University Dental Hospital,  Departments of 2Society Dentistry and 3Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Korea
Eun Joo Choi
Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, 460 Iksan-daero, Iksan 54538, Korea
TEL: +82-63-850-6931   FAX: +82-63-859-4002  E-mail: cejoms@wku.ac.kr
Received June 6, 2016; Revised September 8, 2016; Accepted September 16, 2016.; Published online October 31, 2016.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Abstract (J Korean Assoc Oral Maxillofac Surg 2016;42:271-277)
Objectives: The objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws. Materials and Methods: The 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate. This retrospective study was conducted with patients who were treated in one institute from 2012 to 2013. Fisher’s exact test and logistic regression analysis were used to analyze the odds ratios of diseases having an influence on inhibition of angiogenesis for development of ONJ.Results: The effects of diabetes and hypertension were not statistically significant on development of ONJ. When not considering bisphosphonate use, RA exhibited a high odds ratio of 3.23 (P=0.094), while hyperlipidemia showed an odds ratio of 2.10 (P=0.144) for development of ONJ. More than one disease that had an influence on inhibition of angiogenesis showed a statistically significant odds ratio of 2.54 (P=0.012) for development of ONJ. Conclusion: Patients without diseases having an influence on inhibition of angiogenesis were at less risk for developing ONJ.
Keywords: Bisphosphonate-associated osteonecrosis of the jaw, Angiogenesis inhibitors, Rheumatoid arthritis, Hypercholesterolemia


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