J Korean Assoc Oral Maxillofac Surg 2020; 46(1): 49~57
Prescription of antibiotics after tooth extraction in adults: a nationwide study in Korea
Yoon-Young Choi1,2
1Graduate School of Clinical Dentistry, Korea University, Seoul, 2Private Practice, Anyang, Korea
Yoon-Young Choi
Private Practice, 180 Simin-daero, Dongan-gu, Anyang 14073, Korea
TEL: +82-31-8086-9898 FAX: +82-31-8086-9899
E-mail: dencyy@naver.com
ORCID: https://orcid.org/0000-0002-7973-719X
Received September 23, 2019; Accepted October 28, 2019.; Published online February 29, 2020.
© The Korean Association of Oral and Maxillofacial Surgeons.. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Objectives: This study aimed to understand the nationwide patterns of antibiotic prescription after tooth extraction in adult patients.
Materials and Methods: This study analyzed dental records from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database on 503,725 tooth extractions performed in adults (≥19 years) during 2011-2015. Patient sex, age, household income, systemic disease (diabetes mellitus and hypertension), type of dental institution, region of dental institution, year of prescription, and type of tooth extraction procedure were considered. The antibiotic prescription rate and broad-spectrum antibiotic prescription frequency were analyzed using chi-squared tests. Factors affecting the prescription of broad-spectrum antibiotics were evaluated using multivariate logistic regression analysis.
Results: The rate of antibiotic prescription after tooth extraction was 81.85%. Penicillin was most commonly prescribed (45.25%), followed by penicillin with beta-lactamase inhibitors (18.76%), metronidazole (12.29%), and second- to fourth-generation cephalosporins (11.52%). The proportion of broad-spectrum antibiotics used among all prescribed antibiotics was 45.88%.
Conclusion: The findings of this study demonstrate that the rate of antibiotic prescription after tooth extraction is higher in Korea than in other countries. Furthermore, broad-spectrum antibiotics are used more frequently, which may indicate unnecessary drug prescription, an important contributor to antibiotic resistance.
Keywords: Anti-bacterial agents, Antibiotics, Korea, Prescriptions, Tooth extraction


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29 February 2020
Vol. 46
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