J Korean Assoc Oral Maxillofac Surg 2019; 45(5): 267~275
Role of immunoreactive patterns of lymph nodes in neck dissection cases of oral squamous cell carcinoma: a clinical and histopathological study
Harshada C. Bhatlawande1, Alka D. Kale1, Karishma M. Desai1, Seema Hallikerimath1, Chetan Belaldavar1, Deepa Mane1, Punnya V. Angadi1, Manjula M.1, Sidramesh Muttagi2
Departments of 1Oral Pathology and Microbiology and 2Oral and Maxillofacial Surgery, KLE Academy of Higher Education and Research (KLE University), KLE VK Institute of Dental Sciences and Hospital, Belagavi, India
Harshada C. Bhatlawande
Department of Oral Pathology and Microbiology, KLE Academy of Higher Education and Research (KLE University), KLE VK Institute of Dental Sciences and Hospital, JN Medical College Campus, Nehru Nagar, Belagavi 590010, India
TEL: +91-9970385527 FAX: +0831-2470640
E-mail: harshadacb9@gmail.com
ORCID: https://orcid.org/0000-0002-1509-3209
Received September 17, 2018; Accepted October 30, 2018.; Published online October 31, 2019.
© The Korean Association of Oral and Maxillofacial Surgeons.. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Objectives: Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC.
Materials and Methods: Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated.
Results: The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia ( P =0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade.
Conclusion: The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.
Keywords: Lymph node, Lymphatic metastasis, Squamous cell carcinoma, Neck dissection, Germinal center


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25 October 2019
Vol. 45
No. 5 pp. 231~299

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