J Korean Assoc Oral Maxillofac Surg 2019; 45(4): 225~229
Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis
Mamata Kamat1, Uma Datar1, Sampada Kanitkar2, Sanjay Byakodi3
Departments of 1Oral Pathology & Microbiology and 3Oral & Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, 2Private Clinic, Sangli, India
Mamata Kamat
Department of Oral Pathology & Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Sangli 416416, India
TEL: +91-8412914777 FAX: +91-233-2211324
E-mail: kmamata@yahoo.com
ORCID: https://orcid.org/0000-0003-0167-531X
Received December 26, 2017; Revised March 16, 2018; Accepted March 22, 2018.; Published online August 31, 2019.
© The Korean Association of Oral and Maxillofacial Surgeons.. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt’s lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt’s lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein–Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt’s lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt’s lymphoma is essential among clinicians and pathologists.
Keywords: Aquired immunodeficiency syndrome, Burkitt lymphoma, Gingiva, HIV, Oral cavity


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31 August 2019
Vol. 45
No. 4 pp. 173~230

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