J Korean Assoc Oral Maxillofac Surg 2019; 45(2): 76~82
Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing?
Sam Paul1, Rupshikha Choudhury2, Nandini Kumari3, Sanjay Rastogi4,*, Ashish Sharma4, Vikas Singh5, Shyamalendu Laskar4, Tushar Dubey4
1Department of Orthodontics and Dentofacial Orthopaedics, Educare Institute of Dental Sciences, Malappuram, 2Department of Oral and Maxillofacial Surgery, Regional Dental College, Guwahati, 3Faculty of Dental Sciences, Trauma Centre, Banaras Hindu University, Varanasi, 4Department of Oral and Maxillofacial Surgery, Kothiwal Dental College and Research Centre (KDCRC), Moradabad, 5Department of Public Health Dentistry, Teerthanker Mahaveer Dental College and Research Centre (TMDCRC), Moradabad, India
Sanjay Rastogi
Department of Oral and Maxillofacial Surgery, Mithila Minority Dental College and Hospital (MMDCH), House No. Z-23, Ashiyana Phase 2, Moradabad 244001, India, TEL: +91-8279947254 FAX: +91-8439783274, E-mail: docos79@gmail.com
ORCID: https://orcid.org/0000-0001-8573-3075
Received February 20, 2018; Revised April 16, 2018; Accepted April 21, 2018.; Published online April 30, 2019.
© The Korean Association of Oral and Maxillofacial Surgeons.. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: To appraise the effectiveness of platelet-rich fibrin (PRF) in the management of established dry socket in terms of pain, inflammation, and wound healing.
Materials and Methods: Two hundred patients with established alveolar osteitis were studied to determine the efficacy of PRF and zinc oxide eugenol (ZOE) for pain control, inflammation reduction, and wound healing. Patients were randomly allocated to Group A (PRF) or Group B (ZOE). Patients were examined on the 1st, 3rd, 7th, and 14th postoperative day and evaluated for pain using visual analogue scale scores, inflammation with a gingival index score, and wound healing through a determination of the number of bony walls exposed.
Results: Group A showed better results in terms of pain remission, control of inflammation, and wound healing compared to Group B. Results between groups were statistically significant (P<0.05).
Conclusion: PRF is a better alternative than ZOE for the effective management of alveolar osteitis.
Keywords: Dry socket, Pain, Platelet-rich fibrin, Wound healing

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25 October 2019
Vol. 45
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