J Korean Assoc Oral Maxillofac Surg 2018; 44(6): 289~292
Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects
Zeinab Rezaei Esfahrood1, Zahra Yadegari2, Setareh Kazemi Veysari3, Mahdi Kadkhodazadeh1
Departments of 1Periodontics and 2Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences, 3School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Setareh Kazemi Veysari
School of Dentistry, Shahid Beheshti University of Medical Sciences, Daneshgah Square, Velenjak Street, Tehran 143569414, Iran
TEL: +98-2122181019 FAX: +98-22403194
E-mail: s.kazemiveysari@gmail.com
ORCID: https://orcid.org/0000-0003-3890-1747
Received January 16, 2018; Revised March 11, 2018; Accepted March 12, 2018.; Published online December 31, 2018.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.
Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.
Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005).
Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.
Keywords: Sclerostin, Periodontitis, Gingival crevicular fluid


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