J Korean Assoc Oral Maxillofac Surg 2018; 44(3): 103~106
Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection
Shermil Sayd1, Suresh Vyloppilli2, Krishna Kumar3, Pramod Subash4, Nithin Kumar5, Sarfras Raseel5
1Department of Oral and Maxillofacial Surgery, Kannur Dental College, Anjarakandy Integrated Campus, Kannur,
2Department of Oral and Maxillofacial Surgery and Dentistry, Malankara Orthodox Syrian Church Medical College & Hospital, Kolenchery, Kochi,
3Department of Cleft and Craniomaxillofacial Surgery, Aster MIMS Hospital, Calicut,
4Department of Craniomaxillofacial Surgery, Amrita School of Dentistry, Kochi,
5Department of Oral and Maxillofacial Surgery, KMCT Dental College, Calicut, India
Suresh Vyloppilli
Department of Oral and Maxillofacial Surgery and Dentistry, Malankara Orthodox Syrian Church Medical College & Hospital, Kolenchery, Medical College Road, P O Kolenchery, Kochi 682311, India
TEL: +91-9037019991
E-mail: sureshvyloppilli@gmail.com
ORCID: https://orcid.org/0000-0002-9423-3774
Received September 30, 2017; Revised January 5, 2018; Accepted January 22, 2018.; Published online June 30, 2018.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: The goal of the study was to investigate the clinical effects of amoxicillin-clavulanic acid (500+125 mg) with metronidazole 400 mg administered three times daily (Group I) versus azithromycin 500 mg administered once daily and with metronidazole 400 mg three times daily (Group II) for the prevention of postoperative infection following mandibular third molar surgical removal.
Materials and Methods: The study design was a single-center prospective study. Patients who reported to the Department of Oral and Maxillofacial Surgery between February 2015 and January 2017 for removal of mandibular third molar were screened, and 108 patients were chosen. One surgeon carried out all procedures. Patients were prescribed antibiotics until the two groups contained a similar number of cases.
Results: Our data showed that Group II had fewer incidences of surgical site infection, but with no statistical significance.
Conclusion: Although both treatments are used routinely after removal of the mandibular third molar, neither is significantly better than the other.
Keywords: Impacted third molar removal, Antibiotic prophylaxis, Amoxicillin, Azithromycin, Metronidazole
Fig. 1. Description of patients with surgical site infection under an antibiotic regimen.

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