J Korean Assoc Oral Maxillofac Surg 2018; 44(3): 93~102
Angiogenesis and the prevention of alveolar osteitis: a review study
Mohammad Ali Saghiri1,2, Armen Asatourian3, Nader Sheibani1,2
Departments of 1Ophthalmology and Visual Sciences and 2Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA,
3Angiogenesis Regenerative Medicine Sector, Dr. H. Afsar Lajevardi Research Cluster (DHALC), Shiraz, Iran
Mohammad Ali Saghiri
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 9418 WIMR, Madison, WI 53705, USA
TEL: +1-608-263-3345
E-mail: saghiri@wisc.edu
ORCID: https://orcid.org/0000-0002-5064-7828
Received May 23, 2017; Revised September 2, 2017; Accepted September 13, 2017.; Published online June 30, 2018.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the healing of the alveolar socket following tooth extraction. The inappropriate removal of formed blood clots causes the undesirable phenomenon of alveolar osteitis (AO) or dry socket. In this review, we aimed to investigate whether enhanced angiogenesis contributes to a more effective prevention of AO. The potential pro- or anti-angiogenic activity of different materials used for the treatment of AO were evaluated. An electronic search was performed in the PubMed, MEDLINE, and EMBASE databases via OVID from January 2000 to September 2016 using the keywords mentioned in the PubMed and MeSH (Medical Subject Headings) terms regarding the role of angiogenesis in the prevention of AO. Our initial search identified 408 articles using the keywords indicated above, with 38 of them meeting the inclusion criteria set for this review. Due to the undeniable role of angiogenesis in the socket healing process, it is beneficial if strategies for preventing AO are directed toward more proangiogenic materials and modalities.
Keywords: Dry socket, Endothelial cells, Regeneration


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30 June 2018
Vol. 44
No. 3 pp. 91~139

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