J Korean Assoc Oral Maxillofac Surg 2018; 44(2): 66~72
Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
Seung-Ki Min1, Joo Hee Jeong1, Kang-Min Ahn3, Chong Woo Yoo2, Joo Yong Park1, Sung Weon Choi1
1Oral Oncology Clinic and 2Department of Pathology, Research Institute and Hospital, National Cancer Center, Goyang,
3Department of Oral and Maxillofacial Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Sung Weon Choi
Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea
TEL: +82-31-920-1750 FAX: +82-31-920-1268
E-mail: choiomfs@ncc.re.kr
ORCID: http://orcid.org/0000-0002-2038-2881
Received September 6, 2017; Revised October 20, 2017; Accepted November 7, 2017.; Published online April 30, 2018.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review.
Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method.
Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%.
Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
Keywords: Oral desmoplastic melanoma, Diagnosis, Recurrence, Survival

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30 April 2018
Vol. 44
No. 2 pp. 41~90

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