J Korean Assoc Oral Maxillofac Surg 2017; 43(6): 388~394
Oral lesions associated with human immunodeficiency virus in 75 adult patients: a clinical study
Antoine Berberi1, Georges Aoun2
Departments of 1Oral and Maxillofacial Surgery and 2Oral Medicine and Diagnosis, School of Dentistry, Lebanese University, Beirut, Lebanon
Antoine Berberi
Department of Oral and Maxillofacial Surgery, School of Dentistry, Lebanese University, Campus Rafic Hariri, Hadath 5208-116, Lebanon
TEL: +961-3-731173 FAX: +961-4-533060
E-mail: anberberi@gmail.com
ORCID: http://orcid.org/0000-0002-7658-1361
Received July 22, 2017; Revised September 12, 2017; Accepted September 20, 2017.; Published online December 31, 2017.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: The objective of this study was to investigate the presence of oral lesions in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in a descriptive cross-sectional study, and to establish their presence according to levels of CD4+ cells (including the CD4+/CD8+ cell ratio).
Materials and Methods: A total of 75 patients infected with HIV were included. Oral lesions were observed and classified using World Health Organization classification guidelines. Potential correlations between the presence and severity of oral lesions and CD4+ cells, including the CD4+/CD8+ cell ratio, were studied.
Results: The most frequent oral lesion detected was oral pseudomembranous candidiasis (80.0%), followed by periodontal disease (40.0%), herpetic lesions (16.0%), hairy leukoplakia (16.0%), gingivitis (20.0%), oral ulceration (12.0%), Kaposi’s sarcoma (8.0%), and non-Hodgkin’s lymphoma (4.0%). The CD4+ count was <200 cells/mm3 in 45 cases (60.0%), between 200-500 cells/mm3 in 18 cases (24.0%), and >500 cells/mm3 in 12 cases (16.0%). The mean CD4+ count was 182.18 cells/mm3. The mean ratio of CD4+/CD8+ cells was 0.26. All patients showed at least one oral manifestation.
Conclusion: There was no correlation between the CD4+/CD8+ cell ratio and the presence of oral lesions. The severity of the lesions was more pronounced when the CD4+ cell count was less than 200 cells/mm3.
Keywords: Acquired immunodeficiency syndrome, CD4+, HIV, Oral lesions

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