J Korean Assoc Oral Maxillofac Surg 2017; 43(5): 324~330
Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia
Sunit B. Patel1, Bhari S. Manjunatha2, Vandana Shah3, Nishit Soni4, Rakesh Sutariya5
1Department of Oral Pathology, Ahmedabad Dental College, Ahmedabad, India,
2Department of Oral Biology, Basic Dental Sciences, Faculty of Dentistry, Al-Huwaiyah, Taif University, Taif, Kingdom of Saudi Arabia,
3Department of Oral Pathology, K.M.Shah Dental College, Vadodara,
4Department of Oral Pathology, Karnavati School of Dentistry, Gandhinagar,
5Department of Oral Pathology, Vaidik Dental College, Daman, India
Bhari S. Manjunatha
Department of Oral Biology, Basic Dental Sciences, Faculty of Dentistry, Al-Huwaiyah, Taif University, Taif 21944, Kingdom of Saudi Arabia
TEL: +966-012-7272020 FAX: +966-012-7274299
E-mail: drmanju26@hotmail.com
ORCID: http://orcid.org/0000-0002-4415-2538
Received January 3, 2017; Revised April 30, 2017; Accepted July 5, 2017.; Published online October 31, 2017.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dysplasia and histological grade of OSCC.
Materials and Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evaluated immunohistochemically for p63 and cyclin D1 expression. Protein expression was correlated based on grades of dysplasia and OSCC.
Results: Out of 30 cases of OSCC, 23 cases (76.7%) were cyclin D1 positive and 30 cases (100%) were p63 positive. Out of 30 cases of leukoplakia, 21 cases (70.0%) were cyclin D1 positive and 30 (100%) were p63 positive (P〈0.05).
Conclusion: The overall expression of cyclin D1 and p63 correlated with tumor differentiation, and increases were correlated with poor histological grades, from well-differentiated to poorly-differentiated SCC. Increased cyclin D1 and p63 expression was associated with the severity of leukoplakia. Based on these results cyclin D1 and p63 products can be a useful tool for improved leukoplakia prognosis.
Keywords: Cyclin D1, Immunohistochemistry, Leukoplakia, Oral squamous cell carcinoma, p63


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31 October 2017
Vol. 43
No. 5 pp. 287~360

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