J Korean Assoc Oral Maxillofac Surg 2017; 43(4): 272~275
A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
Massimo Viviano1, Alessandra Addamo1, Serena Cocca2
1Department of Medical Biotechnologies, Dentistry Clinic,
2Department of Medicine, Surgery and Neurosciences, ENT Clinic, University of Siena, Siena, Italy
Serena Cocca
Department of Medicine, Surgery and Neurosciences, ENT Clinic, University of Siena, Viale Bracci, 14, Siena 53100, Italy
TEL: +39-3201525334 FAX: +39-0577585470 E-mail: mailarticoli@libero.it ORCID: http://orcid.org/0000-0003-3485-9967
Received September 5, 2016; Revised October 28, 2016; Accepted November 10, 2016.; Published online August 31, 2017.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
Keywords: Bisphosphonate-associated osteonecrosis of the jaw, Sepsis, Necrotizing fasciitis, Jaw fractures


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31 August 2017
Vol. 43
No. 4 pp. 213~285

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