J Korean Assoc Oral Maxillofac Surg 2017; 43(2): 63~69
The role of nuclear factor I-C in tooth and bone development
Song Yi Roh, Joo-Cheol Park
Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
Joo-Cheol Park
Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
TEL: +82-2-880-2338
FAX: +82-2-878-2338
E-mail: jcapark@snu.ac.kr
Received April 4, 2017; Accepted April 6, 2017.; Published online April 30, 2017.
© Korean Association of Oral and Maxillofacial Surgeons. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
Keywords: Nuclear factor I-C, Dentinogenesis, Osteogenesis, Osteoporosis


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